BDBM50454798 7-Benzylidenenaltrexone::BNTX

SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)C\C(=C/c1ccccc1)C2=O)ccc3O

InChI Key

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50454798   

TargetDelta-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membranes by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  6.20nMAssay Description:Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]DPDPE from Opioid receptor delta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  26nMAssay Description:Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]DAMGO from Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membranes measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]U-69,593 from human kappa opioid receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Kitasato University

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]U-69,593 from human kappa opioid receptor expressed in CHO cell membranes by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  48nMAssay Description:Binding affinity was determined in a crude membrane preparation from guinea pig brain by displacement of [3H]U-69593 from Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50454798(7-Benzylidenenaltrexone | BNTX)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]U69593 from KOR in guinea pig brain membranes measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2019
Entry Details Article
PubMed