BDBM50092365 (R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiophen-2-ylsulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile::(R)-3-Benzyl-1-(1H-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile::(R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile::3-BENZYL-1-(1H-IMIDAZOL-4-YLMETHYL)-4-(THIEN-2-YLSULFONYL)-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE::3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophene-2-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile::BMS-214662::CHEMBL351706

SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1

InChI Key InChIKey=OLCWFLWEHWLBTO-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50092365   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.35nMAssay Description:Inhibition of purified recombinant human farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of geranylgeranyl transferase (GGT1) using Ras-CVLL as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of geranylgeranyl transferase (GGT1) using K-Ras as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant FTaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FTaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human H-rasMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGTPase KRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human K-rasMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGTPase KRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of K-Ras (unknown origin) geranylgeranylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGTPase KRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of K-Ras (unknown origin) farnesylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of HRAS (unknown origin) farnesylationMore data for this Ligand-Target Pair
In DepthDetails
PubMed