BDBM50366775 BENZTROPINE::Benzatropine

SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c1ccccc1)c1ccccc1

InChI Key InChIKey=GIJXKZJWITVLHI-UHFFFAOYSA-N

Data  12 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50366775   

TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 403nMAssay Description:[3H]-Dopamine uptake inhibition in rat caudate putamenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at human recombinant muscarinic receptor M2 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human recombinant muscarinic receptor M3 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human recombinant muscarinic receptor M4 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 1.89E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 118nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporter of rat caudate putamenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 403nMAssay Description:Inhibition of [3H]dopamine uptake in rat caudate putamen tissue.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 2.41E+4nMAssay Description:Inhibition of [3H]citalopram binding to the serotonin transporter in the cynomolgus (macaca fascicularis) monkey caudate-putamen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 312nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter in the cynomolgus (macaca fascicularis) monkey caudate-putamen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 403nMAssay Description:Inhibition of [3H]dopamine uptake in rat caudate putamen.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 118nMAssay Description:Ability to inhibit binding of [3H]WIN-35428 to dopamine transporter in rat caudate putamenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 312nMAssay Description:Displacement of [3H]WIN-35428 from monkey dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50: 2.41E+4nMAssay Description:Binding affinity of [3H]citalopram for serotonin transporter in monkeyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  0.590nMAssay Description:Binding affinity against Muscarinic receptor from rat brain membranes using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]pirenzepine binding at Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  0.950nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  2.60nMAssay Description:Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  7.90nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  118nMAssay Description:Compound was evaluated for its ability to displace [3H]WIN-35428 binding in rat caudate-putamenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  118nMAssay Description:Inhibition of [3H]WIN-35428 binding to the cocaine binding site on the dopamine transporter (DAT) in synaptosomal membrane preparations from rat stri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  118nMAssay Description:Displacement of [3H]WIN-35428 binding to the dopamine transporter in rat caudate putamen tissue.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  118nMAssay Description:Displacement of [3H]WIN-35428 binding to the dopamine transporter (DAT) in Rat Caudate PutamenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  118nMAssay Description:Affinity for rat dopamine transporter using [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  237nMAssay Description:Binding affinity against Dopamine transporter using [125]RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  5.15E+3nMAssay Description:Binding affinity against serotonin transporter using [125]RTI-55More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed