BDBM97676 US8476284, 5::US8497277, 5::US9133201, 5

SMILES C\C=C\C(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=KOMVUMRPJMRZLN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 97676   

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97676(US8497277, 5 | US8476284, 5 | US9133201, 5)
Affinity DataIC50: 20nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2013
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97676(US8497277, 5 | US8476284, 5 | US9133201, 5)
Affinity DataIC50: 20nMpH: 7.4Assay Description:Measurements were performed in a reaction volume of 50 μL using 96-well assay plates. Kinase enzyme, inhibitor, ATP (at the Km for the kinase), an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2013
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97676(US8497277, 5 | US8476284, 5 | US9133201, 5)
Affinity DataIC50: 20nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97676(US8497277, 5 | US8476284, 5 | US9133201, 5)
Affinity DataIC50: 20nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM97676(US8497277, 5 | US8476284, 5 | US9133201, 5)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
Go to US Patent