BDBM92467 2-Thioxanthine, TX2

SMILES c1cc(ccc1CN2c3c([nH]cn3)C(=O)NC2=S)F

InChI Key InChIKey=GMNQNGTVFNOHLD-UHFFFAOYSA-N

Data  4 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 92467   

TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50: 32nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50: 32nMAssay Description:Inhibition of MPO (unknown origin) measured after 15 mins in presence of H2O2 by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetThyroid peroxidase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50: 590nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyeloperoxidase(Human)
Astrazeneca R&D

LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataKd:  2.00E+4nMAssay Description:Displacement of benzhydroxamic acid from native state MPO (unknown origin) by 1D NMR reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)