BDBM91532 1-(methylthio)-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one::1-methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS-0471508.0001::US20230365568, Compound 143::cid_16370143

SMILES CCCn1c2nnc(SC)n2c2ccccc2c1=O

InChI Key InChIKey=QCMQLIPWNDLWDB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 91532   

TargetDNA dC->dU-editing enzyme APOBEC-3G(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM91532(1-methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]qu...)
Affinity DataIC50: 9.90E+4nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetDNA dC->dU-editing enzyme APOBEC-3A(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM91532(1-methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]qu...)
Affinity DataIC50: 9.90E+4nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM91532(1-methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of biotin-Ahx-CETFDPPLHSpTAI-NH2 binding to recombinant human full-length HA-EGFP-tagged Plk1 PBD expressed in HEK293A cells preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM91532(1-methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]qu...)
Affinity DataIC50: 5.00E+4nMAssay Description:An ELISA-based PBD-binding inhibition assay was performed essentially as described previously. Briefly, a biotinylated PBIP1 p-T78 peptide (i.e., Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
Go to US Patent