BDBM9074 10H-indeno[1,2-b]quinolin-11-amine::11H-indeno-[1,2-b]-quinolin-10-ylamine deriv. 1a::CHEMBL60167

SMILES Nc1c2Cc3ccccc3-c2nc2ccccc12

InChI Key InChIKey=CMZUAEAPKGOQSL-UHFFFAOYSA-N

Data  1 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 9074   

TargetCholinesterase(Human)
University of Bologna

LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 4.70E+3nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 350nMAssay Description:In vitro inhibition of acetylcholinesterase, isolated from rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 3.10E+3nMAssay Description:In vitro inhibition of Butyrylcholinesterase from human plasma.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransporter(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of neuronal uptake of Noradrenaline in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 676nMAssay Description:Compound was tested in vitro for inhibitory activity against AcetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetAcetylcholinesterase(Rat)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 480nMAssay Description:Compound was tested in vitro for inhibitory activity against Acetylcholinesterase in rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCarboxylic ester hydrolase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 4.67E+3nMAssay Description:Compound was tested in vitro for inhibitory activity against ButyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetAcetylcholinesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataIC50: 350nMAssay Description:Inhibition of AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM9074(CHEMBL60167 | 10H-indeno[1,2-b]quinolin-11-amine |...)
Affinity DataKi:  210nM IC50: 680nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2006
Entry Details Article
PubMed