BDBM86779 Phthalonitrile analogue, 4h

SMILES Brc1ccc(COc2ccc(C#N)c(c2)C#N)cc1

InChI Key InChIKey=UNQDLDFRWGNDLC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 86779   

TargetAmine oxidase [flavin-containing] A(Human)
North-West University

LigandPNGBDBM86779(Phthalonitrile analogue, 4h)
Affinity DataIC50: 642nMpH: 7.4 T: 2°CAssay Description:MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
North-West University

LigandPNGBDBM86779(Phthalonitrile analogue, 4h)
Affinity DataIC50: 4.80nMpH: 7.4 T: 2°CAssay Description:MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
North-West University

LigandPNGBDBM86779(Phthalonitrile analogue, 4h)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human recombinant MAO-A assessed as kynuramine oxidation to 4-hydroxyquinoline formation by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
North-West University

LigandPNGBDBM86779(Phthalonitrile analogue, 4h)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant MAO-B assessed as kynuramine oxidation to 4-hydroxyquinoline formation by spectrofluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
North-West University

LigandPNGBDBM86779(Phthalonitrile analogue, 4h)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human recombinant MAOB expressed in insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectrophotometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed