BDBM86636 JNK-IN-11

SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2c(nn3ccccc23)-c2ccccc2)cc1

InChI Key InChIKey=OCZDPFMSAKKNRH-UHFFFAOYSA-N

Data  10 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 86636   

TargetMitogen-activated protein kinase 8(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 1.34nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 0.5nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 0.5nMAssay Description:The binding results were confirmed by measuring IC50 for the inhibition of JNK kinase activity by using Z'-LYTE assay format.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of JNK3 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 48nMAssay Description:Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of JNK1 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 9nMAssay Description:Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of JNK2 (unknown origin) after 1 hr incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86636(JNK-IN-11)
Affinity DataEC50:  48nMAssay Description:Inhibition of c-Jun phosphorylation in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM86636(JNK-IN-11)
Affinity DataEC50:  8.60nMAssay Description:Inhibition of c-Jun phosphorylation in human A-375 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of His-tagged human recombinant JNK1 expressed in insect cells incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Harvard Medical School

LigandPNGBDBM86636(JNK-IN-11)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of His-tagged human recombinant JNK2 expressed in baculovirus expression system incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed