BDBM8466 (2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3-methylbutanamide::CHEMBL114272::hydroxamate analogue 2

SMILES COc1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(=O)NO

InChI Key InChIKey=SUEBJDNLBVTIQP-UHFFFAOYSA-N

Data  2 KI  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8466   

TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataIC50: 900nMpH: 7.0 T: 2°CAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataIC50: 170nMAssay Description:Inhibitory activity against human matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Duke University

Curated by ChEMBL
LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataKd:  113nMAssay Description:Binding affinity to stromelysin-1 catalytic domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Duke University

Curated by ChEMBL
LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataKd:  43nMAssay Description:Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataKi:  81nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM8466(CHEMBL114272 | (2R)-N-hydroxy-2-[(4-methoxybenzene...)
Affinity DataKi:  126nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed