BDBM84637 CAS_85760-74-3::CHEMBL240773::NSC_54562::QUINPIROLE::Quinpirole,(-)::US9359372, Quinpirole

SMILES CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12

InChI Key InChIKey=FTSUPYGMFAPCFZ-UHFFFAOYSA-N

Data  113 KI  3 IC50  4 Kd  48 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 168 hits for monomerid = 84637   

TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataIC50: 462nMT: 2°CAssay Description:Each medicament was dissolved in serum-free F12 culture medium containing 100 μM of IBMX. CHO cells which can stably express D2 receptor were pre-...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKd:  3.50E+3nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKd:  1.90E+3nMAssay Description:In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKd:  6.70E+3nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  48nMAssay Description:Effective concentration to stimulate rat Dopamine receptor D2L mediated [3H]thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  8.70nMAssay Description:Effective concentration to stimulate human Dopamine receptor D4.2 mediated [3H]thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  17nMAssay Description:Effective concentration to stimulate rat Dopamine receptor D2S mediated [3H]thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.60nMAssay Description:Effective concentration to stimulate human Dopamine receptor D3 mediated [3H]-thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  330nMAssay Description:Intrinsic activity against dopamine D2(long) receptor expressed in CHO cells by GTPgammaS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  3.40nMAssay Description:Intrinsic activity against dopamine D3 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  7.40nMAssay Description:Intrinsic activity against dopamine D2(long) receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  230nMAssay Description:Intrinsic activity against dopamine D2(short) receptor expressed in CHO cells by GTPgammaS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  11nMAssay Description:Intrinsic activity against dopamine D4 receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  10nMAssay Description:Intrinsic activity against dopamine D2(short) receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  23nMAssay Description:Intrinsic activity against dopamine D4 receptor expressed in CHO cells by GTPgammaS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.60nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as rate of [3H]thymidine incorporation by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHO dhfr mutant cells assessed as stimulation of mitogenesis after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.10nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.90nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in dhfr-deficient CHO cells assessed as [3H]thymidine incorporationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at DRD2 Long receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation by bioluminescence ass...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.20nMAssay Description:Effective concentration of compound required against human Dopamine D4.2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2nMAssay Description:Tested for the effective concentration against CHO 10001 cells in human D4.2 receptor established in mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataIC50: 100nMAssay Description:Displacement of [3H]- -spiperone from Dopamine receptor D2 in rat striatumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Purdue University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [3H]- #NAME from binding Dopamine receptor D1 in rat striatumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  7.60nMAssay Description:In vitro inhibition of forskolin-stimulated cAMP accumulation in GH4C1 cells transfected with the human Dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  3.70nMAssay Description:Effective dose was measured by the stimulation of mitogenesis at Dopamine receptor D4.2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.20nMAssay Description:Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D2L from ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from ratMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataKd:  2.30E+3nMAssay Description:In vitro affinity at mutant D2 receptor (S197A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.20nMAssay Description:Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D2L by mitogenesis assay (intri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.70nMAssay Description:Effective concentration was determined as thymidine uptake in CHO-L6 cells transfected with the rat Dopamine receptor D3 by mitogenesis assay (intrin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  3.10nMAssay Description:Intrinsic activity in mitogenesis assay using Dopamine receptor D3 expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Rat)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  80nMAssay Description:Basal binding towards Dopamine receptor D3 was evaluated using [35S]- GTP-gamma S radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  19nMAssay Description:Effective concentration from [3H]thymidine uptake assay in CHO10001 cells expressing human Dopamine receptor D4.2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.40nMAssay Description:Effective concentration in [3H]thymidine uptake assay by CHO dhfr- mutant cells expressing human D3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  49nMAssay Description:Effective concentration for [35S]GTP-gamma-S, binding in CHO-K1 cells expressing human dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  2.60nMAssay Description:Effective concentration against dopamine D3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.40nMAssay Description:Activity at human D4.2 receptor assessed as [3H]thymidine incorporation in CHO 10001 cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  49nMAssay Description:Activity at human D4.4 receptor expressed in CHOK1 cells assessed as stimulation of [35S]GTP-gammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  9nMAssay Description:Activity at rat dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  5nMAssay Description:Binding affinity to human cloned dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  9.90nMAssay Description:Effective concentration for [3H]thymidine uptake in growing CHO cells stably expressing the dopamine D4.2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  240nMAssay Description:Agonist activity at dopamine D2 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  8.40nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine i...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  31nMAssay Description:Agonist effect on the Dopamine D4.2 receptor was determined by evaluating effective concentration causing stimulation of mitogenesisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoA ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  64nMAssay Description:Agonist activity at ARMS2-PK2 tagged D2S receptor (unknown origin) expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin-2 recru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM84637(NSC_54562 | CHEMBL240773 | QUINPIROLE | CAS_85760-...)
Affinity DataEC50:  151nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells assessed as induction of renilla luciferase 2-tagg...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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