BDBM8226 3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione::4-arylmaleimide deriv. 6i

SMILES COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O

InChI Key InChIKey=DQYDZCRLDYVZKY-UHFFFAOYSA-N

Data  2 KI  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 8226   

TargetTyrosine-protein kinase JAK3(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused JAK3 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of biotinylated full-length STK10 expressed in Escherichia coli DH10Bac assessed as transfer of radiolabelled phosphate from ATP by OMNIA ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of NanoLuc-fused CLK4 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase 33(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of NanoLuc-fused STK3 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase 25(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused YSK1 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase tousled-like 1(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of NanoLuc-fused TLK1 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase tousled-like 2(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused TLK2 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of NanoLuc-fused GSK3A (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase DCLK3(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused DCAMKL3 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 700nMAssay Description:Inhibition of NanoLuc-fused SLK (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 114nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GSK3beta (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GSK3alpha (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of CLK2 (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of STK10 (unknown origin) expressed in Sf9 cells assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of SLK (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataIC50: 114nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataKi:  6.60nMAssay Description:Binding affinity human SLK by binding displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM8226(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)
Affinity DataKi:  46nMAssay Description:Binding affinity human STK10 by binding displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed