BDBM8195 4-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridazin-3-yl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-2-amine::D3RKN_74::pyrazolo[1,5-b]pyridazine deriv. 86

SMILES Clc1ccc(cc1)-c1nn2ncccc2c1-c1ccnc(Nc2ccc3OCCOc3c2)n1

InChI Key InChIKey=SALHUFFLOPHDJC-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 8195   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8195(4-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridazin-3-yl...)
Affinity DataIC50: 2.00E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8195(4-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridazin-3-yl...)
Affinity DataIC50: 796nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
LigandPNGBDBM8195(4-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridazin-3-yl...)
Affinity DataKd:  9.00E+3nMAssay Description:D3R2021More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM8195(4-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridazin-3-yl...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2022More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

LigandPNGBDBM8195(4-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridazin-3-yl...)
Affinity DataKd:  52nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R