BDBM8131 N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine::N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 22

SMILES CC(C)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1

InChI Key InChIKey=UODXTGBFBIFREQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 8131   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 31nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 1.99E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK4 by radioactive glutathione plate-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 16nMAssay Description:Inhibition of GSK3-beta by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human CDK2 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetCyclin-K(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 20nMAssay Description:Inhibition of CDK9/Cyclin K (unknown origin) by LanthaScreen binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-C(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) by LanthaScreen binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Nankai University

Curated by ChEMBL
LigandPNGBDBM8131(N-[4-(propan-2-yl)phenyl]-4-{pyrazolo[1,5-a]pyrida...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of CDK19/Cyclin C (unknown origin) by LanthaScreen binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed