BDBM7884 1-methyl-1H-imidazole::US9138393, 1-Methylimidazole::US9144538, 1-Methylimidazole

SMILES Cn1ccnc1

InChI Key InChIKey=MCTWTZJPVLRJOU-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 7884   

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM7884(1-methyl-1H-imidazole | US9138393, 1-Methylimidazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM7884(1-methyl-1H-imidazole | US9138393, 1-Methylimidazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM7884(1-methyl-1H-imidazole | US9138393, 1-Methylimidazo...)
Affinity DataIC50: 2.70E+6nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
LigandPNGBDBM7884(1-methyl-1H-imidazole | US9138393, 1-Methylimidazo...)
Affinity DataKi:  2.30E+4nM ΔG°:  -6.43kcal/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2006
Entry Details Article
PubMed
LigandPNGBDBM7884(1-methyl-1H-imidazole | US9138393, 1-Methylimidazo...)
Affinity DataKi:  3.00E+4nM ΔG°:  -6.27kcal/molepH: 8.0 T: 2°CAssay Description:QC activity was evaluated fluorometrically using Gln-AMC as substrate, and pyroglutamyl peptidase as the auxiliary enzyme. After conversion of Gln-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2006
Entry Details Article
PubMed