BDBM7814 Maleimide-Related Compound 13::pyrrolidine-2,5-dione

SMILES O=C1CCC(=O)N1

InChI Key InChIKey=KZNICNPSHKQLFF-UHFFFAOYSA-N

Data  6 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 7814   

TargetGlycogen synthase kinase-3 beta [7-25](Rabbit)
Instituto De Quimica Medica (Csic)

LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2006
Entry Details Article
PubMed
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2017
Entry Details Article
PubMed
TargetProtein cereblon(Human)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataIC50: 3.45E+4nMAssay Description:Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2017
Entry Details Article
PubMed
TargetProtein cereblon(Human)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataIC50: 2.23E+4nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataIC50: 3.53E+3nMAssay Description:Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataKi:  642nMAssay Description:Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2017
Entry Details Article
PubMed
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataKi:  4.30E+3nMAssay Description:Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataKi:  8.19E+3nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein cereblon(Human)
Max Planck Institute For Developmental Biology

Curated by ChEMBL
LigandPNGBDBM7814(pyrrolidine-2,5-dione | Maleimide-Related Compound...)
Affinity DataKi:  2.62E+4nMAssay Description:Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2017
Entry Details Article
PubMed