BDBM7270 2,3-dimethoxy-9-trifluoromethylpaullone::4,5-dimethoxy-14-(trifluoromethyl)-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::CHEMBL328194::NSC 702378::Paullone Analog 9

SMILES COc1cc2NC(=O)Cc3c([nH]c4ccc(cc34)C(F)(F)F)-c2cc1OC

InChI Key InChIKey=RVTOIQOTZUKDTE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 7270   

LigandPNGBDBM7270(4,5-dimethoxy-14-(trifluoromethyl)-8,18-diazatetra...)
Affinity DataIC50: 280nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM7270(4,5-dimethoxy-14-(trifluoromethyl)-8,18-diazatetra...)
Affinity DataIC50: 430nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM7270(4,5-dimethoxy-14-(trifluoromethyl)-8,18-diazatetra...)
Affinity DataIC50: 75nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
UniversitäT Hamburg

Curated by ChEMBL
LigandPNGBDBM7270(4,5-dimethoxy-14-(trifluoromethyl)-8,18-diazatetra...)
Affinity DataIC50: 280nMAssay Description:In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM7270(4,5-dimethoxy-14-(trifluoromethyl)-8,18-diazatetra...)
Affinity DataIC50: 280nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM7270(4,5-dimethoxy-14-(trifluoromethyl)-8,18-diazatetra...)
Affinity DataIC50: 75nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed