BDBM702847 ((S)-2,2-difluorocyclopropyl)(3-(2-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone::US20240360157, Example 201

SMILES Cn1cc(-c2nc3c(N4CC5CCC(C4)N5C(=O)[C@@H]4CC4(F)F)ccnc3[nH]2)cn1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 702847   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702847(((S)-2,2-difluorocyclopropyl)(3-(2-(1-methyl-1H-py...)
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Biogen Ma

US Patent
LigandPNGBDBM702847(((S)-2,2-difluorocyclopropyl)(3-(2-(1-methyl-1H-py...)
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Biogen Ma

US Patent
LigandPNGBDBM702847(((S)-2,2-difluorocyclopropyl)(3-(2-(1-methyl-1H-py...)
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [3-974](Human)
Biogen Ma

US Patent
LigandPNGBDBM702847(((S)-2,2-difluorocyclopropyl)(3-(2-(1-methyl-1H-py...)
Affinity DataIC50: 164nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2025
Entry Details
Go to US Patent