BDBM701133 US20240343747, Example B37

SMILES CCC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2cc(P(=O)(C3CC3)C3CC3)n(C)n2)c1OC

InChI Key InChIKey=ZAXDGWKGUHYRCK-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 701133   

TargetNon-receptor tyrosine-protein kinase TYK2 [575-869](Human)
Accro Bioscience (HK)

US Patent
LigandPNGBDBM701133(US20240343747, Example B37)
Affinity DataKd:  0.0440nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Accro Bioscience (HK)

US Patent
LigandPNGBDBM701133(US20240343747, Example B37)
Affinity DataKd: >3.00E+4nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Accro Bioscience (HK)

US Patent
LigandPNGBDBM701133(US20240343747, Example B37)
Affinity DataKd: >3.00E+4nMAssay Description:The lysates were centrifuged and filtered to remove cell debris. The remaining kinases were produced in HEK-293 cells and subsequently tagged with DN...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent