BDBM700887 N-(2-((2-chloropyrimidin-4- yl)amino)phenyl)benzene- sulfonamide::US20240343694, Example 14

SMILES O=S(=O)(Nc1ccccc1Nc2ccnc(Cl)n2)c3ccccc3

InChI Key InChIKey=HRUMSDFICXUFED-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 700887   

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700887(N-(2-((2-chloropyrimidin-4- yl)amino)phenyl)benzen...)
Affinity DataIC50: 1nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
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TargetEpidermal growth factor receptor [1-763,'FHEA',764-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700887(N-(2-((2-chloropyrimidin-4- yl)amino)phenyl)benzen...)
Affinity DataIC50: 2nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700887(N-(2-((2-chloropyrimidin-4- yl)amino)phenyl)benzen...)
Affinity DataIC50: 410nMAssay Description:The activity of the compounds of the present invention against HER mutant enzymes was measured using the HTRF system purchased by Cisbio as follows. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent