BDBM700880 US20240343694, Example 7::tert-butyl (5-acrylamido-4-((2- (dimethylamino)ethyl(methyl) amino)-2-methoxyphenyl)carbamate

SMILES C=CC(=O)Nc1cc(NC(=O)OC(C)(C)C)c(OC)cc1N(C)CCN(C)C

InChI Key InChIKey=AHKADPGTHXIDQX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 700880   

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700880(tert-butyl (5-acrylamido-4-((2- (dimethylamino)eth...)
Affinity DataIC50: 1nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
2/23/2025
Entry Details
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TargetEpidermal growth factor receptor [1-763,'FHEA',764-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700880(tert-butyl (5-acrylamido-4-((2- (dimethylamino)eth...)
Affinity DataIC50: 5nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
2/23/2025
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700880(tert-butyl (5-acrylamido-4-((2- (dimethylamino)eth...)
Affinity DataIC50: 280nMAssay Description:The activity of the compounds of the present invention against HER mutant enzymes was measured using the HTRF system purchased by Cisbio as follows. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent