BDBM700865 US20240343694, Example 4::tert-butyl (4-fluoro-2-methoxy-5- nitrophenyl)carbamate

SMILES COc1cc(F)c([N+](=O)[O-])cc1NC(=O)OC(C)(C)C

InChI Key InChIKey=KPUXYKMAEDAWET-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 700865   

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700865(tert-butyl (4-fluoro-2-methoxy-5- nitrophenyl)carb...)
Affinity DataIC50: 1nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
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TargetEpidermal growth factor receptor [1-763,'FHEA',764-1210](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700865(tert-butyl (4-fluoro-2-methoxy-5- nitrophenyl)carb...)
Affinity DataIC50: 2nMAssay Description:The activity of the compounds of the present invention against EGFR mutant enzymes was measured using the HTRF system purchased from Cisbio as follow...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Reserarch Institute of Chemical Technology

US Patent
LigandPNGBDBM700865(tert-butyl (4-fluoro-2-methoxy-5- nitrophenyl)carb...)
Affinity DataIC50: 37nMAssay Description:The activity of the compounds of the present invention against HER mutant enzymes was measured using the HTRF system purchased by Cisbio as follows. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent