BDBM699469 Cyclobut-1-en-1-yl(3-(1-(4- (trifluoromethoxy)phenyl)-1H- pyrazolo[3,4-b]pyrazin-3-yl)azetidin-1- yl)methanone::US12110276, Compound 163

SMILES FC(F)(F)Oc1ccc(cc1)-n1nc(C2CN(C2)C(=O)C2=CCC2)c2nccnc12

InChI Key InChIKey=KQRNWDALNMUUOG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699469   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699469(Cyclobut-1-en-1-yl(3-(1-(4- (trifluoromethoxy)phen...)
Affinity DataIC50: 11nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699469(Cyclobut-1-en-1-yl(3-(1-(4- (trifluoromethoxy)phen...)
Affinity DataIC50: 8.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699469(Cyclobut-1-en-1-yl(3-(1-(4- (trifluoromethoxy)phen...)
Affinity DataIC50: 10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699469(Cyclobut-1-en-1-yl(3-(1-(4- (trifluoromethoxy)phen...)
Affinity DataIC50: 5.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent