BDBM699375 (E)-4,4-difluoro-N-[[4- (hydroxymethyl)-1-[4- (trifluoromethoxy)phenyl]pyrazolo[3,4- b]pyridin-3-yl]methyl]but-2-enamide::US12110276, Compound 69

SMILES OCc1ccnc2n(nc(CNC(=O)\C=C\C(F)F)c12)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=OWLSOTDTUQFGNX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699375   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699375((E)-4,4-difluoro-N-[[4- (hydroxymethyl)-1-[4- (tri...)
Affinity DataIC50: 6.10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699375((E)-4,4-difluoro-N-[[4- (hydroxymethyl)-1-[4- (tri...)
Affinity DataIC50: 14nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699375((E)-4,4-difluoro-N-[[4- (hydroxymethyl)-1-[4- (tri...)
Affinity DataIC50: 51nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699375((E)-4,4-difluoro-N-[[4- (hydroxymethyl)-1-[4- (tri...)
Affinity DataIC50: 5.40nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent