BDBM699358 N-[[4-(3-cyanoazetidin-1-yl)-1-[4- (trifluoromethoxy)phenyl]pyrazolo[3,4- b]pyridin-3-yl]methyl]prop-2-enamide::US12110276, Compound 52

SMILES FC(F)(F)Oc1ccc(cc1)-n1nc(CNC(=O)C=C)c2c(ccnc12)N1CC(C1)C#N

InChI Key InChIKey=CCXNSTCXCYECAJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 699358   

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM699358(N-[[4-(3-cyanoazetidin-1-yl)-1-[4- (trifluorometho...)
Affinity DataIC50: 14nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM699358(N-[[4-(3-cyanoazetidin-1-yl)-1-[4- (trifluorometho...)
Affinity DataIC50: 45nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM699358(N-[[4-(3-cyanoazetidin-1-yl)-1-[4- (trifluorometho...)
Affinity DataIC50: 3.50E+3nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM699358(N-[[4-(3-cyanoazetidin-1-yl)-1-[4- (trifluorometho...)
Affinity DataIC50: 3.40nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
Go to US Patent