BDBM698784 US20240317756, Compound 1

SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCCN1C(=O)C=C

InChI Key InChIKey=LCYSSHSIKSARGO-UHFFFAOYSA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 698784   

TargetTyrosine-protein kinase Lyn(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 16.2nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 10.4nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 2nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 0.5nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 11.7nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 0.5nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 1.00E+4nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 10.4nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fer(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 8.07E+3nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase CSK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 2.20nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetProtein-tyrosine kinase 6 (BRK)(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 3.30nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 86.1nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Yes(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 6.5nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 0.5nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase HCK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 3.70nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fyn(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 95.6nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fgr(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 2.30nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 263nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Blk(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 0.5nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 2nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 0.100nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 9.40nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 0.5nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Tec(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 77.8nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 0.800nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM698784(US20240317756, Compound 1)
Affinity DataIC50: 11.7nMAssay Description:For enzyme inhibition assays, compounds were tested in range of ten concentrations from 10 uM to 0.0005 uM using purified enzymes and the Hotspot kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
Go to US Patent