BDBM696514 Synthesis of (2S,6aS,6bR,7S,8aS,8bS,10R,11aR,12aS,12bS)-10-(4-((7-amino-2,3-dihydrobenzofuran-4-yl)methyl)phenyl)-2,6b-difluoro- 7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2′,1′:4,5]indeno[1,2-d][1,3]dioxolan-4(2H)-one ::US20240307415, Compound 010

SMILES C[C@]12C[C@H](O)[C@@]3(F)[C@@H](C[C@H](F)C4=CC(=O)C=C[C@]34C)[C@@H]1C[C@H]1O[C@H](O[C@@]21C(=O)CO)c1ccc(Cc2ccc(N)c3OCCc23)cc1

InChI Key InChIKey=KVGOKEONYILWQH-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 696514   

TargetGlucocorticoid receptor(Human)
Jiangsu Simcere Pharmaceutical Co.

US Patent
LigandPNGBDBM696514(Synthesis of (2S,6aS,6bR,7S,8aS,8bS,10R,11aR,12aS,...)
Affinity DataEC50:  16.4nMAssay Description:The binding activity of the compound to GR was determined using the Polarscreen Glucocorticoid Receptor Assay Kit, Red (brand: Thermo, Cat. No: A1589...More data for this Ligand-Target Pair
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US Patent

TargetSteroid hormone receptor ERR1(Human)
Jiangsu Simcere Pharmaceutical Co.

US Patent
LigandPNGBDBM696514(Synthesis of (2S,6aS,6bR,7S,8aS,8bS,10R,11aR,12aS,...)
Affinity DataEC50:  52nMAssay Description:The binding activity of the compound to ER was determined using the LanthaScreen TR-FRET ER Alpha Coactivator Assay kit (brand: Thermo, Cat. No: A158...More data for this Ligand-Target Pair
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US Patent

TargetAndrogen receptor(Human)
Jiangsu Simcere Pharmaceutical Co.

US Patent
LigandPNGBDBM696514(Synthesis of (2S,6aS,6bR,7S,8aS,8bS,10R,11aR,12aS,...)
Affinity DataEC50: >3.00E+4nMAssay Description:The binding activity of the compound to AR was determined using the LanthaScreen TR-FRET Androgen Receptor Coactivator Assay kit (brand: Thermo, Cat....More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetProgesterone receptor(Human)
Jiangsu Simcere Pharmaceutical Co.

US Patent
LigandPNGBDBM696514(Synthesis of (2S,6aS,6bR,7S,8aS,8bS,10R,11aR,12aS,...)
Affinity DataEC50: >3.00E+4nMAssay Description:The binding activity of the compound to PR was determined using the LanthaScreen TR-FRET Progesterone Receptor Coactivator Assay kit (brand: Thermo, ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent