BDBM695734 N-(bicyclo[1.1.1]pentan-1-yl)-2-fluoro- 5-(5$#8243;-(methylsulfonamido) dispiro[cyclopropane-1,1'-cyclohexane- 4',3$#8243;-indoline]-1$#8243;- carbonyl)benzenesulfonamide::US12084420, Compound 337

SMILES CS(=O)(=O)Nc1ccc2N(CC3(CCC4(CC4)CC3)c2c1)C(=O)c1ccc(F)c(c1)S(=O)(=O)NC12CC(C1)C2

InChI Key InChIKey=DNIPOLASAPMHOH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 695734   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695734(US12084420, Compound 337 | N-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 8.80nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
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Date in BDB:
1/6/2025
Entry Details
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