BDBM695698 N-(1$#8243;-(3-((3,3-difluoroazetidin-1- yl)sulfonyl)-4- hydroxybenzoyl)dispiro[cyclopropane- 1,1$#8243;-cyclohexane-4$#8243;,3$#8243;-indolin]-5$#8243;- yl)methanesulfonamide::US12084420, Compound 303

SMILES CS(=O)(=O)Nc1ccc2N(CC3(CCC4(CC4)CC3)c2c1)C(=O)c1ccc(O)c(c1)S(=O)(=O)N1CC(F)(F)C1

InChI Key InChIKey=JJFRZBMXYKWFKS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 695698   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695698(US12084420, Compound 303 | N-(1$#8243;-(3-((3,3-di...)
Affinity DataIC50: 8.20nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent