BDBM695676 N-(tert-butyl)-4-(5$#8243;-((2- hydroxyethyl)sulfonamido)dispiro [cyclopropane-1,1'-cyclohexane-4',3$#8243;- indoline]-1$#8243;-carbonyl)thiophene-2-sulfonamide::US12084420, Compound 274

SMILES CC(C)(C)NS(=O)(=O)c1cc(cs1)C(=O)N1CC2(CCC3(CC3)CC2)c2cc(NS(=O)(=O)CCO)ccc12

InChI Key InChIKey=QYYCCXXNJQUDIM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 695676   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695676(US12084420, Compound 274 | N-(tert-butyl)-4-(5$#82...)
Affinity DataIC50: 6nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
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Date in BDB:
1/6/2025
Entry Details
Go to US Patent