BDBM695665 N-(1$#8243;-(3-((3,3-difluoroazetidin-1- yl)sulfonyl)benzoyl)dispiro[cyclopropane- 1,1'-cyclohexane-4',3$#8243;-indolin]-5$#8243;- yl)methanesulfonamide::US12084420, Compound 257

SMILES CS(=O)(=O)Nc1ccc2N(CC3(CCC4(CC4)CC3)c2c1)C(=O)c1cccc(c1)S(=O)(=O)N1CC(F)(F)C1

InChI Key InChIKey=LALNZEAXUGTMHH-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 695665   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695665(US12084420, Compound 257 | N-(1$#8243;-(3-((3,3-di...)
Affinity DataIC50: 8.30nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695665(US12084420, Compound 257 | N-(1$#8243;-(3-((3,3-di...)
Affinity DataKi:  0.960nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent