BDBM695644 N-(1$#8243;-(3-((2-azaspiro[3.3]heptan-2- yl)sulfonyl)benzoyl)dispiro[cyclopropane- 1,1'-cyclohexane-4',3$#8243;-indolin]-5$#8243;- yl)-2-hydroxyethane-1-sulfonamide::US12084420, Compound 228

SMILES OCCS(=O)(=O)Nc1ccc2N(CC3(CCC4(CC4)CC3)c2c1)C(=O)c1cccc(c1)S(=O)(=O)N1CC2(CCC2)C1

InChI Key InChIKey=GAOPSGVVELYUCP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 695644   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695644(US12084420, Compound 228 | N-(1$#8243;-(3-((2-azas...)
Affinity DataIC50: 4.60nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent