BDBM695639 N-(bicyclo[1.1.1]pentan-1-yl)-3-(5$#8243;- (methylsulfonamido)dispiro[cyclopropane- 1,1'-cyclohexane-4',3$#8243;-indoline]- 1$#8243;-carbonyl)benzenesulfonamide::US12084420, Compound 223

SMILES CS(=O)(=O)Nc1ccc2N(CC3(CCC4(CC4)CC3)c2c1)C(=O)c1cccc(c1)S(=O)(=O)NC12CC(C1)C2

InChI Key InChIKey=KHZILFRMHYCEFX-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 695639   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695639(US12084420, Compound 223 | N-(bicyclo[1.1.1]pentan...)
Affinity DataIC50: 6.70nMAssay Description:Table 9: Test compounds were plated in a 3× dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM695639(US12084420, Compound 223 | N-(bicyclo[1.1.1]pentan...)
Affinity DataKi:  0.260nMAssay Description:Table 10: Compound binding kinetics parameters (kon and koff) were determined by the method of global progress curve analysis (GPCA). KIF18A (0.25 nM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/6/2025
Entry Details
Go to US Patent