BDBM695199 US20240294551, Example 365

SMILES C[C@@]12COCCN(C1)c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c(F)c(ncc13)-c1c3[C@@H](CCc3cc3[nH]ncc13)CCOC(=O)O2

InChI Key InChIKey=PRZVDBFMBXVOGK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 695199   

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM695199(US20240294551, Example 365)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM695199(US20240294551, Example 365)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent