BDBM694934 US20240294551, Example 100

SMILES F[C@H]1CN2CCC[C@@]2(COc2nc3N4CCCC[C@H](C4)OC(=O)OCCCc4c(Cl)cc5[nH]ncc5c4-c4ncc3c(n2)c4F)C1

InChI Key InChIKey=VPTHCLMFFQUMRY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 694934   

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM694934(US20240294551, Example 100)
Affinity DataIC50: 2nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM694934(US20240294551, Example 100)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent