BDBM694925 US20240294551, Example 91

SMILES CC1COC(=O)O[C@@H]2CCCN(C2)c2nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c(F)c(ncc23)-c2c(C1)c(Cl)cc1[nH]ncc21

InChI Key InChIKey=PLEQHPYAOCRVEU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 694925   

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM694925(US20240294551, Example 91)
Affinity DataIC50: 4nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM694925(US20240294551, Example 91)
Affinity DataIC50: 2nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent