BDBM694856 US20240294551, Example 22

SMILES CN(C)CC1(COc2nc3N4CCC[C@](C)(C4)NC(=O)CCCc4c(F)ccc5cc(O)cc(-c6ncc3c(n2)c6F)c45)CC1

InChI Key InChIKey=OYOLEBPMOKLYJW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 694856   

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM694856(US20240294551, Example 22)
Affinity DataIC50: 3nMAssay Description:Compounds of interest were prepared in a dose-response titration in DMSO, and 80 nL were added via Labcyte Echo to each well of a 384-well plate (Per...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Amgen

US Patent
LigandPNGBDBM694856(US20240294551, Example 22)
Affinity DataIC50: 1nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12D and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent