BDBM694467 US20240293412, Compound TABLE2.20

SMILES CSc1ccc(CNC(=O)[C@@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1

InChI Key InChIKey=VWUOWUZLQDJSCV-UHFFFAOYSA-N

Data  1 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694467   

TargetNicotinamide phosphoribosyltransferase(Human)
University of Nebraska

Curated by ChEMBL
LigandPNGBDBM694467(US20240293412, Compound TABLE2.20)
Affinity DataEC50:  37nMAssay Description:Activation of NAMPT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Nebraska

Curated by ChEMBL
LigandPNGBDBM694467(US20240293412, Compound TABLE2.20)
Affinity DataEC50:  40nMAssay Description:Positive allosteric modulation of C-terminal His6-tagged wild type human NAMPT using NAM and PRPP as substrates measured for 1 hr by NMNAT1-coupled e...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Nebraska

Curated by ChEMBL
LigandPNGBDBM694467(US20240293412, Compound TABLE2.20)
Affinity DataKd:  265nMAssay Description:Displacement of FP-probe ZN-2-102 from C-terminal His6-tagged wild type human NAMPT rear channel assessed as dissociation constant by fluorescence po...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Nebraska

Curated by ChEMBL
LigandPNGBDBM694467(US20240293412, Compound TABLE2.20)
Affinity DataEC50:  40nMAssay Description:All FP measurements were performed at room temperature in PBS buffer containing 0.01% Triton-X 100 and 1% DMSO in black 384-well plates. Measurements...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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