BDBM694077 US20240287079, Example 252

SMILES CC(C)CNc1nc2nn(cc2c(=O)[nH]1)-c1c(C)cc(Br)cc1C

InChI Key InChIKey=HWXMWHGHQDYUKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 694077   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM694077(US20240287079, Example 252)
Affinity DataIC50: 2.60nMAssay Description:The NLRP3 inflammasome inhibitory activity of test compounds were evaluated on the basis of the inhibitory activity of the IL-1β production in T...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
Go to US Patent

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM694077(US20240287079, Example 252)
Affinity DataIC50: 3nMAssay Description:Inhibition of NLRP3 in human THP-1 cells assessed as reduction in IL-1beta productionMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed