BDBM689089 (S)-6-(6-chloro-5-fluoro-2-oxo- 1,2- dihydrospiro[benzo[d][1,3] oxazine-4,3'-pyrrolidin]-1'- yl)-N-(4-((3-fluoroazetidin-1- yl)methyl)benzyl)pyridazine-4- carboxamide::US20240190892, Example 47

SMILES FC1CN(Cc2ccc(CNC(=O)c3cnnc(c3)N3CC[C@]4(C3)OC(=O)Nc3ccc(Cl)c(F)c43)cc2)C1

InChI Key InChIKey=PEHVECFKNKWWHW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 689089   

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM689089(US20240190892, Example 47 | (S)-6-(6-chloro-5-fluo...)
Affinity DataIC50: 13.8nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of plasma kallikrein can be determined using a relevant purified serine prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
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TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM689089(US20240190892, Example 47 | (S)-6-(6-chloro-5-fluo...)
Affinity DataIC50: 1.00E+4nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent