BDBM689082 N-((6-(3-Azabicyclo[3.1.0]hexan-3- yl)pyridin-3-yl)methyl)-6-((S)-6- chloro-5-fluoro-2-oxo-1,2- dihydrospiro[benzo[d][1,3]oxazine- 4,3'-pyrrolidin]-1'-yl)pyrazine-2- carboxamide::US20240190892, Example 40

SMILES Fc1c(Cl)ccc2NC(=O)O[C@@]3(CCN(C3)c3cncc(n3)C(=O)NCc3ccc(nc3)N3CC4CC4C3)c12

InChI Key InChIKey=JPTKZUHECQEYOD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 689082   

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM689082(US20240190892, Example 40 | N-((6-(3-Azabicyclo[3....)
Affinity DataIC50: 18.6nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of plasma kallikrein can be determined using a relevant purified serine prot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
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TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM689082(US20240190892, Example 40 | N-((6-(3-Azabicyclo[3....)
Affinity DataIC50: 1.00E+4nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent