BDBM688741 (E)-3-(6-amino-7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)acrylamide::US20240190872, Compound (+-)-Debio-1452-NH3

SMILES CN(Cc1oc2ccccc2c1C)C(=O)\C=C\c1cnc2NC(=O)[C@H](N)Cc2c1

InChI Key InChIKey=AEHIWLAQKTVLCP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688741   

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli (strain K12))
University of Illinois

US Patent
LigandPNGBDBM688741(US20240190872, Compound (+-)-Debio-1452-NH3 | (E)-...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADH]()
University of Illinois

US Patent
LigandPNGBDBM688741(US20240190872, Compound (+-)-Debio-1452-NH3 | (E)-...)
Affinity DataKi:  114nMAssay Description:To probe the effects of varying ring systems and amine placement on FabI target engagement, the apparent inhibition constants (Kiapp) for select comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent