BDBM688512 1-((2- (methylamino)pyrimidin- 5-yl)methyl)-N-(4-((4- methylpiperazin-1- yl)methyl)-3- (trifluoromethyl)phenyl) indoline-6-carboxamide::US20240190847, Example 12

SMILES CNc1ncc(CN2CCc3ccc(cc23)C(=O)Nc2ccc(CN3CCN(C)CC3)c(c2)C(F)(F)F)cn1

InChI Key InChIKey=OZBQFWXDQIGUPB-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 688512   

TargetEpithelial discoidin domain-containing receptor 1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM688512(US20240190847, Example 12 | 1-((2- (methylamino)py...)
Affinity DataIC50: 10nMAssay Description:DDR1 and DDR2 binding assays were performed using Life Technologies LanthaScreen Europium Kinase Binding assay. The compounds were incubated with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM688512(US20240190847, Example 12 | 1-((2- (methylamino)py...)
Affinity DataKi: <10nMAssay Description:DDR1 and DDR2 binding assays were performed using Life Technologies LanthaScreen Europium Kinase Binding assay. The compounds were incubated with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetDiscoidin domain-containing receptor 2(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM688512(US20240190847, Example 12 | 1-((2- (methylamino)py...)
Affinity DataKi:  37.5nMAssay Description:DDR1 and DDR2 binding assays were performed using Life Technologies LanthaScreen Europium Kinase Binding assay. The compounds were incubated with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent