BDBM688400 US20240189315, Ex. 4.04 of PCT/EP2022/062480)

SMILES C[C@@H]1N(CCOC11COC1)c1cccnc1O[C@H]1C[C@H](N(C1)c1nc(nc2c3ccccc3oc12)C(F)F)C(O)=O

InChI Key InChIKey=JUSHRXPDFOMKDJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 688400   

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480))
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent