BDBM685883 US12043625, Ex. 2.12::US12043625, Example 2.12

SMILES C[C@H]1CS(=O)(=O)CC[C@]1(F)c1cc(cnc1O[C@H]1C[C@H](N(C1)c1nc(nc2c3ccccc3oc12)C(F)(F)F)C(O)=O)C#C

InChI Key InChIKey=NTIAWLYLGQHMRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 685883   

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent