BDBM681989 US12018014, Compound Formula 5

SMILES CNN1CCN(CC1)C(=O)Nc1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C

InChI Key InChIKey=CIVSWNZKBWESRB-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 681989   

TargetALK tyrosine kinase receptor(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 4.90E+3nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 110nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 2.34E+3nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
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TargetTyrosine-protein kinase receptor UFO(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 284nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 8.80nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
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TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 1.5nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3 [D835Y](Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 17.3nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 190nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 891nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
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TargetSphingosine kinase 2(Human)
Suzhou Genhouse Pharmaceutical Co.

US Patent
LigandPNGBDBM681989(US12018014, Compound Formula 5)
Affinity DataIC50: 286nMAssay Description:Successful drug candidate compounds were subjected to numerous biochemical and cellular assays. Purified bacterial β-glucuronidases were challen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2024
Entry Details
Go to US Patent