BDBM681819 US20240199644, Compound 16

SMILES Oc1cc(-c2cc3OC[C@H]4[C@H]5C[C@H](CN5)N4c4nc(OCC5(CN6CCOCC6)CC5)nc(c2F)c34)c2c(cccc2c1)C#C

InChI Key InChIKey=CRMIZBNBHMVHJV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 681819   

LigandPNGBDBM681819(US20240199644, Compound 16)
Affinity DataIC50: 86.1nMAssay Description:GppNp-loaded HIS-KRAS(G12D, aa 1-169) was pre-incubated with a compound in the presence of 200 uM GTP in a 384-well plate (Greiner) for 15 min, then ...More data for this Ligand-Target Pair
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Date in BDB:
9/24/2024
Entry Details
Go to US Patent