BDBM681817 US20240199644, Compound 14

SMILES Oc1cc(-c2cc3OC[C@@H]4[C@@H]5CC[C@H](CN4c4nc(OCC6(CN7CCOCC7)CC6)nc(c2F)c34)N5)c2c(C#C)c(F)ccc2c1

InChI Key InChIKey=SGZXZFYWIAUQIW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 681817   

LigandPNGBDBM681817(US20240199644, Compound 14)
Affinity DataIC50: 1.15nMAssay Description:GppNp-loaded HIS-KRAS(G12D, aa 1-169) was pre-incubated with a compound in the presence of 200 uM GTP in a 384-well plate (Greiner) for 15 min, then ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent