BDBM681808 US20240199644, Compound 5
SMILES Oc1cc(-c2cc3OC[C@@H]4[C@@H]5CC[C@H](CN4c4nc(OCC6(CN7CCOCC7)CC6)nc(c2F)c34)N5)c2c(cccc2c1)C#C
InChI Key InChIKey=CCEZKZBORPCURK-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 681808
TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [1-169,G12D](Human)
Jacobio Pharmaceuticals
US Patent
Jacobio Pharmaceuticals
US Patent
Affinity DataIC50: 1.16nMAssay Description:GppNp-loaded HIS-KRAS(G12D, aa 1-169) was pre-incubated with a compound in the presence of 200 uM GTP in a 384-well plate (Greiner) for 15 min, then ...More data for this Ligand-Target Pair