BDBM681806 US20240199644, Compound 3

SMILES Oc1cc(-c2cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4N5CCNC[C@@H]5COc(c2Cl)c34)c2ccccc2c1

InChI Key InChIKey=TXXVTOIGGLYKGW-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 681806   

TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [1-169,G12D](Human)
Jacobio Pharmaceuticals

US Patent

LigandBDBM681806(US20240199644, Compound 3)Copy SMILESCopy InChI

Affinity DataIC50: 294nMAssay Description:GppNp-loaded HIS-KRAS(G12D, aa 1-169) was pre-incubated with a compound in the presence of 200 uM GTP in a 384-well plate (Greiner) for 15 min, then ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/24/2024
Entry Details
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